Pharmaceutical, Biotechnology, and Life Sciences

For the Life Science, Pharmaceutical, Biotechnology, and Nutraceutical industries, Brawn Mixer brings decades of experience in both process expertise and compliance management. Many processes in these industries are sensitive, with rigorous documentation requirements. Brawn Mixer will work as an expert partner to develop effective, repeatable mixing solutions which meet these standards.

Processes

  • Liquid-liquid blending
  • Solid suspension
  • Dissolution
  • Gas dispersion
  • Emulsions
  • Multi-phase
  • Heat transfer
  • High viscosity
  • Living cell cultures
  • Fermentation
  • Media preparation

Design Capabilities

  • FDA/USDA documentation
  • Open/closed tank
  • High temperature
  • High pressure
  • Special alloy wetted parts
  • Hazardous environment
  • Sanitary/CIP construction
  • Low-shear

Mixing Solutions

B Series Portable Mixers: ⅓ - 5 HP heavy duty mixers

M Series Portable Mixers: ⅓ - ¾ HP medium duty mixers

BTO/BTR Series Industrial Mixers: High capacity industrial mixers

Side Entry Mixers: Gear- or belt-driven configurations available

Brawn Process Advantages

Technical Documentation

For many pharmaceutical and life science processes, validation is critical to bringing a process into production. The Brawn Mixer technical writing team can provide compliant documentation for all standard and custom regulatory frameworks. Proper operating, installation, and service manuals, engineering drawings, and process and instrument diagrams are available as part of our comprehensive documentation packages. Contact a representative for more detail on Brawn Mixer compliance management.

Application Engineering Expertise

The Brawn application engineering group is tightly integrated at each step in the sales and order process, from initial specification review to design and testing. Brawn Mixer application engineers recommend solutions based on customer requirements, specifications, and objectives, while keeping in mind other considerations like budgetary requirements. Additionally, the applications group has the capability to perform bench and pilot scale mixing tests in order to scale-up to production levels.

Bench, Pilot, and Full-Scale Testing

Recognizing that many pharmaceutical applications rely on the effectiveness and precision of mixing and blending process as much as they rely on component ingredients, the Brawn application engineering team has developed comprehensive testing protocols. Tools like computational fluid dynamics software help engineering develop solutions for even the most challenging applications, while dedicated testing facilities enable the Brawn R&D team to refine models developed during the design phase. Bench, pilot, and full-scale implementation studies also often play a crucial role for customers, especially for validation and economic viability prediction.

Hygienic Mixer Design

Applications with hygienic or sanitary specifications are common in the pharmaceutical, biotechnology, and life science industries. The Brawn Mixer application engineering team evaluates the entire process chain, and takes into account risk factors that extend beyond the mixing operation alone to ensure each mixer contributes positively to overall quality, safety, and optimization goals. Mixers can be designed to conform to applicable standards from all major regulatory bodies, including the FDA, cGMP, USDA, and USP. Comprehensive documentation to fulfill validation requirements is also available.

Brawn mixers designed to meet hygienic standards are cleanable via either customer or OEM-supplied SIP or CIP systems. All-stainless-steel construction is available for many mixer configurations; drive assemblies can also be coated with Steel-It paint.

Data Reporting and Integration

Brawn mixers can integrate with local process equipment, or with operation-wide SCADA systems, to improve process control and real-time reporting. Increasingly, isolated islands of process equipment are being replaced or upgraded with integrated systems that deliver greater performance. Brawn mixers can be configured at the factory to interface with these systems with minimum complexity. And, our installation and service team can provide onsite support for startup and commissioning.